PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsEstradiol valerate
Depo-testadiol, Zoely(estradiol valerate)
Activella, Amabelz, Angeliq, Bijuva, Climara, Combipatch, Delestrogen, Depo-testadiol, Ditate, Divigel, Elestrin, Estrace, Estradiol, Estradiol /, Estrasorb, Estring, Estrogel, Etyqa, Evamist, Femring, Imvexxy, Ioa, Lunelle, Menostar, Minivelle, Myfembree, Natazia, Ryeqo, Vagifem, Vivelle-dot, Zoely (estradiol valerate) is a small molecule pharmaceutical. Estradiol valerate was first approved as Estrace on 1982-01-01. It is used to treat breast neoplasms, hot flashes, hypogonadism, menorrhagia, and premature menopause amongst others in the USA. It has been approved in Europe to treat contraception and leiomyoma.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
therapeuticsD013812
reproductive and urinary physiological phenomenaD012101
Trade Name
FDA
EMA
Climara, Delestrogen, Divigel, Elestrin, Estring, Estrogel, Evamist, Femring, Imvexxy, Menostar, Minivelle, Vagifem, Vivelle-dot (generic drugs available since 1982-01-01, discontinued: Alora, Esclim, Estrace, Estraderm, Estrasorb, Fempatch, Femtrace, Gynodiol, Innofem, Vivelle)
Combinations
Activella, Angeliq, Bijuva, Climara, Combipatch, Etyqa, Myfembree, Natazia (generic drugs available since 1982-01-01, discontinued: Depo-testadiol, Ditate, Lunelle, Prefest)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dienogest
+
Estradiol valerate
Tradename
Company
Number
Date
Products
NATAZIABayerN-022252 RX2010-05-06
1 products, RLD, RS
Drospirenone
+
Estradiol
Tradename
Company
Number
Date
Products
ANGELIQBayerN-021355 RX2005-09-28
2 products, RLD, RS
Estradiol
Tradename
Company
Number
Date
Products
ESTROGELAscend TherapeuticsN-021166 RX2004-02-09
1 products, RLD, RS
CLIMARABayerN-020375 RX1994-12-22
6 products, RLD, RS
MENOSTARBayerN-021674 RX2004-06-08
1 products, RLD, RS
IMVEXXYMayne GroupN-208564 RX2018-05-29
2 products, RLD, RS
ELESTRINMylanN-021813 RX2006-12-15
1 products, RLD, RS
MINIVELLENoven PharmaceuticalsN-203752 RX2012-10-29
5 products, RLD, RS
VAGIFEMNovo NordiskN-020908 RX2009-11-25
1 products, RLD, RS
EVAMISTPadagisN-022014 RX2007-07-27
1 products, RLD, RS
ESTRINGMylanN-020472 RX1996-04-26
1 products, RLD, RS
VIVELLE-DOTSandozN-020538 RX1999-01-08
5 products, RLD, RS
Show 1 marketed
Show 8 discontinued
Estradiol
+
Levonorgestrel
Tradename
Company
Number
Date
Products
CLIMARA PROBayerN-021258 RX2003-11-21
1 products, RLD, RS
Estradiol
+
Norethindrone acetate
Tradename
Company
Number
Date
Products
ACTIVELLAAmneal PharmaceuticalsN-020907 RX1998-11-18
1 products, RLD, RS
COMBIPATCHNoven PharmaceuticalsN-020870 RX1998-08-07
2 products, RLD, RS
Show 1 discontinued
Estradiol
+
Norethindrone acetate
+
Relugolix
Tradename
Company
Number
Date
Products
MYFEMBREEMyovant SciencesN-214846 RX2021-05-26
1 products, RLD, RS
Estradiol
+
Norgestimate
Tradename
Company
Number
Date
Products
PREFESTTevaN-021040 DISCN1999-10-22
1 products, RLD
Hide discontinued
Estradiol
+
Progesterone
Tradename
Company
Number
Date
Products
BIJUVAMayne GroupN-210132 RX2018-10-28
2 products, RLD, RS
Estradiol acetate
Tradename
Company
Number
Date
Products
FEMRINGMillicent PharmaN-021367 RX2003-03-20
2 products, RLD, RS
Show 1 discontinued
Estradiol cypionate
+
Medroxyprogesterone acetate
Tradename
Company
Number
Date
Products
LUNELLEPharmacia & UpjohnN-020874 DISCN2000-10-05
1 products
Hide discontinued
Estradiol cypionate
+
Testosterone cypionate
Tradename
Company
Number
Date
Products
DEPO-TESTADIOLPharmacia & UpjohnN-017968 DISCN1982-01-01
1 products
Hide discontinued
Estradiol hemihydrate
Tradename
Company
Number
Date
Products
ESTRASORBExeltisN-021371 DISCN2003-10-09
1 products, RLD
Hide discontinued
Estradiol valerate
Tradename
Company
Number
Date
Products
DELESTROGENPar PharmaceuticalN-009402 RX1982-01-01
3 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
activellaNew Drug Application2020-03-31
afirmelleANDA2021-02-17
aloraOTC monograph not final2019-09-18
altaveraANDA2022-03-01
alyacen 1/35ANDA2023-06-07
alyacen 1/35 alyacen 7/7/7ANDA2017-09-08
alyacen 7/7/7ANDA2021-03-18
amabelzANDA2024-01-10
amethiaANDA2022-08-16
amethystANDA2022-01-31
Show 258 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
breast neoplasmsEFO_0003869D001943C50
hot flashes—D019584—
hypogonadismHP_0000044D007006E23.0
menorrhagiaHP_0000132D008595N92.0
premature menopauseHP_0008209D008594E28.31
primary ovarian insufficiencyEFO_0004266D016649E28.3
prostatic neoplasms—D011471C61
Agency Specific
FDA
EMA
Expiration
Code
ESTRADIOL / NORETHINDRONE ACETATE / RELUGOLIX, MYFEMBREE, MYOVANT SCIENCES
2026-01-27M-289
2025-12-18NCE
2025-08-05I-898
2024-05-26NP
ESTRADIOL, ESTRADIOL, CHEMO RESEARCH SL
2023-04-08CGT
Patent Expiration
Patent
Expires
Flag
FDA Information
Estradiol / Norethindrone Acetate / Relugolix, Myfembree, Myovant Sciences
117938122038-05-03U-2360
110335512037-09-29U-3129
117951782033-09-27DS, DP
93468222024-02-17U-3129
73009352024-01-28DP
80582802024-01-28DP
Estradiol, Imvexxy, Mayne Pharma
112666612034-02-02U-2316, U-2317
91800912033-12-20DPU-2316, U-2317
102586302033-12-20U-2316, U-2317
103987082033-12-20U-2317, U-2614
104710722033-06-18U-2316, U-2317
105688912033-06-18U-2316, U-2317
106680822033-06-18U-2316, U-2317
108885162033-06-18U-2316, U-2317
110651972033-06-18DP
111167172033-06-18DP
111232832033-06-18DP
92893822032-11-21DP
105375812032-11-21DPU-2316, U-2317
108066972032-11-21DP
108354872032-11-21U-2316, U-2317
112414452032-11-21U-2316, U-2317
112468752032-11-21U-2316, U-2317
113049592032-11-21DP
113511822032-11-21U-2316, U-2317
114977092032-11-21U-2316, U-2317
Estradiol / Progesterone, Bijuva, Mayne Pharma
86331782032-11-21DP
88466482032-11-21U-2439
88466492032-11-21DPU-2439
89330592032-11-21DPU-2439
89872372032-11-21DP
89935482032-11-21DP
89935492032-11-21DP
90062222032-11-21DPU-2439
91141452032-11-21U-2439
91141462032-11-21DPU-2439
93019202032-11-21DPU-2439
100523862032-11-21DP
102069322032-11-21U-2439
106393752032-11-21DP
106752882032-11-21U-2439
108067402032-11-21DPU-2439
110336262032-11-21DPU-2439
111035132032-11-21U-2439
111035162032-11-21DP
111100992032-11-21DP
111669632032-11-21DP
115293602032-11-21DP
117938192032-11-21U-2439
Drospirenone / Estradiol, Angeliq, Bayer Hlthcare
89068902031-10-22DP
Estradiol, Minivelle, Noven
82319062030-07-04DS, DP
97243102028-07-10DS, DP
97309002028-07-10U-2086
98334192028-07-10DP
Dienogest / Estradiol Valerate, Natazia, Bayer Hlthcare
81536162028-01-30U-1240
80715772026-05-13DPU-1
Estradiol Acetate, Femtrace, Apil
75727792025-10-02U-904
ATC Codes
No data
HCPCS
Code
Description
J1380
Injection, estradiol valerate, up to 10 mg
Clinical
Clinical Trials
594 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ContraceptionD003267——12522141063
MenopauseD008593EFO_0003922N95971314647
InfertilityD007246HP_0000789—224121938
Healthy volunteers/patients———28423—34
Polycystic ovary syndromeD011085EFO_0000660E28.24—271225
Breast neoplasmsD001943EFO_0003869C5011321521
Hot flashesD019584———393318
PostmenopauseD017698——2364316
EndometriosisD004715EFO_0001065N80—373214
Female infertilityD007247EFO_0008560N971—13510
Show 69 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Premenstrual syndromeD011293—N94.3114—28
Prostatic neoplasmsD011471—C61—52——6
Anorexia nervosaD000856EFO_0004215F50.0221——5
SchizophreniaD012559EFO_0000692F20—32——5
AtrophyD001284———22——4
AdenomyosisD062788EFO_1001757N80.01—1—13
Metabolic bone diseasesD001851HP_0000938——12——3
Premenstrual dysphoric disorderD065446—F32.81—21——3
Migraine disordersD008881EFO_0003821G43121——3
ObesityD009765EFO_0001073E66.9——1—12
Show 17 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382—U07.1—3———3
NeoplasmsD009369—C8011———2
Feeding and eating disordersD001068—F50—2———2
Bulimia nervosaD052018EFO_0005204F50.2—2———2
Temporomandibular joint disordersD013705—M26.6—1——12
FibromyalgiaD005356EFO_0005687M79.1—1——12
Endometrial neoplasmsD016889EFO_0004230——2———2
Orthostatic intoleranceD054971———1———1
Ovarian diseasesD010049———1———1
HemostasisD006487———1———1
Show 20 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Therapeutic equivalencyD013810——10———111
PharmacokineticsD010599——5————5
Drug interactionsD004347——3———14
Type 1 diabetes mellitusD003922EFO_0001359E101———12
Type 2 diabetes mellitusD003924EFO_0001360E112————2
Hepatitis cD006526—B19.22————2
Systemic lupus erythematosusD008180HP_0002725M321———12
TransgenesD019076——1————1
Cerebral arterial diseasesD002539EFO_1000859—1————1
InfectionsD007239EFO_0000544—1————1
Show 10 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Psychological sexual dysfunctionsD020018—F52.0————22
Heart disease risk factorsD000082742——————11
Premature menopauseD008594HP_0008209E28.31————11
Breast densityD000071060——————11
Cognitive dysfunctionD060825HP_0001268G31.84————11
Blood pressureD001794EFO_0004325—————11
Pulmonary embolismD011655HP_0002204I26————11
Intracranial sinus thrombosisD012851——————11
Postmenopausal osteoporosisD015663EFO_0003854—————11
HemorrhageD006470MP_0001914R58————11
Show 11 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameEstradiol valerate
INNestradiol valerate
Description
Estradiol valerate is a steroid ester.
Classification
Small molecule
Drug classestrogens
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@]12C
Identifiers
PDB—
CAS-ID979-32-8
RxCUI—
ChEMBL IDCHEMBL1511
ChEBI ID31561
PubChem CID13791
DrugBankDB13956
UNII IDOKG364O896 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Bijuva – TherapeuticsMD
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Divigel – RVL Pharmaceuticals
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Ryeqo – Myovant Sciences
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Myfembree – Myovant Sciences
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Imvexxy – TherapeuticsMD
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Estradiol – Amneal Pharmaceuticals
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 130,349 documents
View more details
Safety
Black-box Warning
Black-box warning for: Activella, Altavera, Amabelz, Amethia, Angeliq, Annovera, Ashlyna, Aurovela 1.5/30, Aurovela 24 fe, Ayuna, Azurette, Balcoltra, Beyaz, Bijuva, Blisovi 24 fe, Blisovi fe 1.5/30, Blisovi fe 1/20, Camrese, Camrese lo, Camreselo, Charlotte 24fe, Chateal eq, Climara, Climara pro, Climarapro, Combipatch (estradiol/norethindrone acetate transdermal system), Cryselle, Cyclafem 7/7/7, Cyonanz, Cyred eq, Dasetta 1/35, Dasetta 7/7/7, Daysee, Delestrogen, Depo-estradiol, Desogestrel and ethinyl estradiol, Divigel, Dotti, Drospirenone and ethinyl estradiol, Drospirenone, ethinyl estradiol and levomefolate calcium and levomefolate calcium, Drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium, Elestrin, Elinest, Eluryng, Enilloring, Enskyce, Estarylla, Estra-25 estra-50, Estrace, Estradiol, Estradiol / norethindrone acetate, Estradiol and norethindrone acetate, Estradiol and progesterone, Estradiol transdermal system, Estradiol vaginal, Estradiol vaginal cream, Estradiol vaginal inserts, Estradiol valerate, Estradiol valerate and estradiol valerate/dienogest, Estring, Estrogel, Etonogestrel and ethinyl estradiol, Etonogestrel and ethinyl estradiol vaginal, Etonogestrel and ethinyl estradiol vaginal ring, Etonogestrel/ethinyl estradiol, Evamist, Femring, Femynor, Finzala, Fyavolv, Gemmily, Hailey 24 fe, Hailey fe 1.5/30, Hailey fe 1/20, Iclevia, Imvexxy, Introvale, Isibloom, Jaimiess, Jasmiel, Jinteli, Jolessa, Joyeaux, Juleber, Junel, Junel fe, Kaitlib fe, Kalliga, Kurvelo, Larin 1.5/30, Larin 1/20, Larin 24 fe, Larin fe 1/20, Layolis fe, Levonorgestrel and ethinyl estradiol and ethinyl estradiol, Levonorgestrel/ethinyl estradiol and ethinyl estradiol, Levora, Lo loestrin fe, Lo simpesse, Lo-zumandimine, Loestrin, Loestrin 24 fe, Lojaimiess, Lopreeza, Loryna, Loseasonique, Low-ogestrel, Lyllana, Marlissa, Melodetta 24 fe, Menostar, Mibelas 24 fe, Microgestin 1.5/30, Microgestin 1/20, Microgestin 24 fe, Microgestin fe 1/20, Mili, Mimvey, Mimvey mimvey lo, Minivelle, Mono-linyah, Mononessa, Myfembree, Natazia, Necon, Nexesta fe, Nikki, Norelgestromin and ethinly estradiol, Norelgestromin and ethinyl estradiol, Norethindrone acetate and ethinyl estradiol and ferrous fumarate, Norethindrone acetate and ethinyl estradiol, and ferrous fumarate, Norethindrone and ethinyl estradiol, Norethindrone and ethinyl estradiol and ferrous fumarate, Norgestimate and ethinyl estradiol, Nuvaring, Nylia 1/35, Nylia 7/7/7, Nymyo, Ocella, Oriahnn, Ortho tri-cyclen lo, Portia, Previfem, Quartette, Rivelsa, Safyral, Seasonique, Setlakin, Simpesse, Sprintec, Syeda, Tarina 24 fe, Taysofy, Taytulla, Tilia fe, Tri femynor, Tri-estarylla, Tri-legest fe, Tri-linyah, Tri-lo- estarylla, Tri-lo-marzia, Tri-lo-mili, Tri-lo-sprintec, Tri-mili, Tri-nymyo, Tri-sprintec, Tri-vylibra, Tri-vylibra lo, Trinessa, Turqoz, Twirla, Tyblume, Tydemy, Vagifem, Vestura, Vivelle dot, Vivelle-dot, Vylibra, Wera, Wymzya fe, Xulane, Yasmin, Yaz, Yuvafem, Zafemy, Zarah, Zenchent fe, Zumandimine
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
86,007 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use